A Foundational Mannequin for Joint Sequence-Perform Lengthy-Vary Genomic Prediction

This webinar, brought to you by Twist Bioscience, will be hosted live and available on-demand.

Wednesday, April 22nd, 2026
11:00 AM – 12:00 PM ET

Genomic prediction and design require models capable of integrating local sequence features with long-range regulatory dependencies. Nucleotide Transformer v3 (NTv3) is a multi-species genomic foundation model that unifies long-range sequence modeling, base-resolution functional prediction, genome annotation, and controllable sequence generation within a single efficient architecture. NTv3 achieves state-of-the-art performance on functional-track and genome-annotation benchmarks across species, consolidates shared regulatory grammar for long-range genome-to-function inference, and supports variant interpretation. 

In this webinar, brought to you by Twist Bioscience, Bernardo Almeida will describe the key design principles of NTv3, explain how it supports controllable sequence generation, and discuss the biological and practical implications of long-context modeling.

Topics to be covered

• Why long-range, base-resolution modeling is essential for accurate genome-to-function prediction
• NTv3’s architecture, training strategy, and multispecies scope
• How NTv3 unifies prediction, annotation, interpretation, and generation within a single foundation model
• How NTv3-generated sequences are experimentally validated
• The implications of long-context modeling for regulatory inference, variant interpretation, and sequence design

Bernardo Almeida, PhD Head of Genomics AI Research InstaDeep